Selleck製品は、NatureやScience等の権威ある科学雑誌に掲載された論文中で数多く使用されています。
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 600(7890):731-736
- Nature, 2021, 600(7888):319-323
- Nature, 2021, 600(7888):314-318
- Nature, 2021, 600(7888):285-289
- Nature, 2021, 599(7886):667-672
- Nature, 2021, 599(7884):308-314
- Nature, 2021, 599(7884):302-307
- Nature, 2021, 598(7881):483-488
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 599(7886):679-683
- Nature, 2021, 598(7881):510-514
- Nature, 2021, 597(7875):263-267
- Nature, 2021, 595(7869):730-734
- Nature, 2021, 595(7868):596-599
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 596(7871):262-267
- Nature, 2021, 592(7856):789-793
- Nature, 2021, 593(7858):275-281
- Nature, 2021, 594(7863):442-447
- Nature, 2021, 593(7860):586-590
- Nature, 2021, 593(7859):440-444
- Nature, 2021, 591(7850):438-444
- Nature, 2021, 590(7846):492-497
- Nature, 2021, 590(7844):129-133
- Nature, 2021, 591(7851):627-632
- Nature, 2021, 591(7851):620-626
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 591(7849):288-292
- Nature, 2021, 10.1038/s41586-021...
- Nature, 2021, 590(7844):151-156
- Nature, 2020, 588(7838):509-514
- Nature, 2020, 588(7838):491-497
- Nature, 2020, 588(7838):479-484
- Nature, 2020, 588(7836):164-168
- Nature, 2020, 588(7836):157-163
- Nature, 2020, 588(7836):130-134
- Nature, 2020, 587(7835):626-631
- Nature, 2020, 586(7829):434-439
- Nature, 2020, 586(7828):292-298
- OMEGA x SWATCH Moonswatch Mission To Saturn BRAND NEW UNOPENED!
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 585(7825):426-432
- Nature, 2020, 585(7824):283-287
- Nature, 2020, 583(7817):620-624
- Nature, 2020, 586(7827):101-107
- Nature, 2020, 584(7822):608-613
- Nature, 2020, doi: 10.1038/s41586...
- Nature, 2020, 583(7818):845-851
- Nature, 2020, 583(7818):852-857
- Nature, 2020, 580(7801):124-129
- Nature, 2020, 580(7803):391-395
- Nature, 2020, 582(7811):289-293
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 580(7804):517-523
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 578(7795):444-448
- Nature, 2020, 577(7791):537-542
- Nature, 2020, 580(7802):257-262
- Nature, 2020, 579(7798):284-290
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- Nature, 2020, 580(7801):147-150
- Nature, 2020, 578(7794):296-300
- Nature, 2020, 580(7801):136-141
- Nature, 2020, 579(7797):118-122
- Nature, 2020, 10.1038/s41586-020...
- Nature, 2020, 577(7788):109-114
- Nature, 2020, 577(7788):115-120
- Nature, 2019, 575(7781):203-209
- Nature, 2019, 575(7783):523-527
- Nature, 2019, 74(7779):571-574
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 573(7775):595-599
- Nature, 2019, 573(7775):539-545
- Nature, 2019, 571(7763):127-131
- Nature, 2019, 573(7774):421-425
- Nature, 2019, 573(7774):439-444
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 569(7755):270-274
- Nature, 2019, 572(7768):254-259
- Nature, 2019, 10.1038/s41586-019...
- Nature, 2019, 572(7769):335-340
- Nature, 2019, 572(7770):538-542
- Nature, 2019, 569(7757):509-513
- Nature, 2019, 569(7756):423-427
- Nature, 2019, 567(7748):405-408
- Nature, 2019, 566(7743):270-274
- Nature, 2019, 566(7744):344-349
- Nature, 2019, 567(7749):521-524
- Nature, 2019, 567(7749):540-544
- Nature, 2019, 567(7747):262-266
- Nature, 2019, 567(7746):118-122
- Nature, 2019, 565(7741):659-663
- Nature, 2019, 565(7740):505-510
- Nature, 2018, 562(7728):526-531
- Nature, 2018, 563(7730):265-269
- Nature, 2018, 563(7733):701-704
- Nature, 2018, 563(7729):131-136
- Nature, 2018, 559(7713):211-216
- Nature, 2018, 560(7718):372-376
- Nature, 2018, 560(7716):112-116
- Nature, 2018, 559(7713):285-289
- Nature, 2018, 560(7718):387-391
- Nature, 2018, 561(7724):551-555
- Nature, 2018, 560(7718):325-330
- Nature, 2018, 560(7716):117-121
- Nature, 2018, 560(7719):499-503
- Nature, 2018, 558(7708):141-145
- Nature, 2018, 559(7713):279-284
- Nature, 2018, 555(7694):103-106
- Nature, 2018, 554(7692):317-322
- Nature, 2018, 555(7698):673-677
- Nature, 2018, 555(7696):387-391
- Nature, 2018, 556(7702):501-504
- Nature, 2018, 557(7704):247-251
- Nature, 2018, 557(7704):256-260
- Nature, 2018, 553(7686):101-105
- Nature, 2018, 553(7686):96-100
- Nature, 2018, 553(7686):91-95
- Nature, 2017, 541(7635):87-91
- Nature, 2017, 544(7649):212-216
- Nature, 2017, 546(7657):302-306
- Nature, 2017, 542(7642):489-493
- Nature, 2017, 546(7659):533-538
- Nature, 2017, 546(7656):168-172
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- Nature, 2017, 547(7664):453-457
- Nature, 2017, 549(7673):548-552
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- Nature, 2017, 551(7679):247-250
- Nature, 2017, 550(7675):270-274
- Nature, 2017, 550(7676):402-406
- Nature, 2017, 552(7683):121-125
- Nature, 2017, 550(7677):534-538
- Nature, 2017, 552(7683):116-120
- Nature, 2017, 551(7678):105-109
- Nature, 2017, 551(7682):639-643
- Nature, 2017, 550(7674):133-136
- Nature, 2017, 550(7676):360-365
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- Nature, 2017, 548(7668):471-475
- Nature, 2017, 548(7667):343-346
- Nature, 2017, 546(7658):431-435
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- Nature, 2017, 541(7638):481-487
- Nature, 2017, 542(7641):362-366
- Nature, 2017, 545(7654):360-364
- Nature, 2017, 546(7658):370-375
- Nature, 2017, 547(7661):109-113
- Nature, 2017, 548(7665):112-116
- Nature, 2017, 544(7651):493-497
- Nature, 2016, 535(7611):303-7
- Nature, 2016, 532(7599):389-93
- Nature, 2016, 531(7595):518-22
- Nature, 2016, 539(7630):570-574
- Nature, 2016, 539(7629):452-455
- Nature, 2016, 534(7609):647-51
- Nature, 2016, 539(7627):54-58
- Nature, 2016, 540(7631):119-123
- Nature, 2016, 539(7629):437-442
- Nature, 2016, 539(7628):304-308
- Nature, 2016, 538(7626):477-482
- Nature, 2016, 535(7613):517-22
- Nature, 2016, 537(7620):422-426
- Nature, 2016, 530(7590):358-61
- Nature, 2016, 534(7607):341-6
- Nature, 2016, 32(7597):107-11
- Nature, 2016, 531(7596):651-5
- Nature, 2016, 534(7607):407-411
- Nature, 2016, 529(7587):532-6
- Nature, 2016, 529(7586):413-417
- Nature, 2016, 540(7632):270-275
- Nature, 2016, 536(7616):338-43
- Nature, 2015, 526(7573):443-7
- Nature, 2015, 524(7564):234-8
- Nature, 2015, 518(7538):258-62
- Nature, 2015, 517(7535):460-5
- Nature, 2015, 519(7542):247-50
- Nature, 2015, 528(7582):422-6
- Nature, 2015, 522(7557):492-6
- Nature, 2015, 527(7576):100-4
- Nature, 2015, 522(7556):349-53
- Nature, 2015, 521(7552):316-21
- Nature, 2015, 521(7553):541-4
- Nature, 2015, 520(7549):683-7
- Nature, 2015, 518(7538):254-7
- Nature, 2015, 517(7534):391-5
- Nature, 2015, 522(7555):226-30
- Nature, 2015, 523(7558):92-5
- Nature, 2015, 521(7552):357-61
- Nature, 2015, 520(7547):368-72
- Nature, 2015, 524(7566):471-5
- Nature, 2015, 517(7536):583-8
- Nature, 2015, 519(7543):370-3
- Nature, 2015, 525(7567):56-61
- Nature, 2015, 521(7550):43-7
- Nature, 2015, 521(7551):232-6
- Nature, 2015, 519(7541):57-62
- Nature, 2015, 523(7559):183-188
- Nature, 2015, 528(7583):570-4
- Nature, 2014, 511(7507):90-3
- Nature, 2014, 510(7504):283-7
- Nature, 2014, 508(7494):118-22
- Nature, 2014, 509(7498):105-9
- Nature, 2014, 514(7524):628-32
- Nature, 2014, 516(7530):254-8
- Nature, 2013, 500(7461):222-6
- Nature, 2013, 496(7446):523-7
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 498(7452):109-12
- Nature, 2013, 502(7471):327-332
- Nature, 2013, 504(7478):138-42
- Nature, 2012, 487(7408):505-9
- Nature, 2012, 483(7387):100-3
- Nature, 2012, 486(7404):532-6
- Nature, 2011, 478(7369):349-55
- Nature, 2011, 471(7337):235-9
- Nature, 2011, 470(7334):419-23
- Nature, 2010, 468(7326):973-7
- Nature, 2010, 468(7326):968-72
- Science, 2021, 371(6535)eabc5386
- Science, 2021, 372(6537)eaba1786
- Science, 2021, 371(6528)eabd0811
- Science, 2020, 370(6521)eabe9403
- Science, 2020, 370(6519)eabb8598
- Science, 2020, 370(6513)eabc2754
- Science, 2020, 369(6510):eaas8995
- Science, 2019, 364(6447)
- Science, 2019, 365(6454)
- Science, 2019, 364(6441)
- Science, 2019, 363(6434)
- Science, 2019, 363(6429)
- Science, 2018, 362(6417)
- Science, 2018, 361(6405)
- Science, 2018, 359(6378)
- Science, 2017, 358(6367):eaan4368
- Science, 2017, eaal3755
- Science, 2017, 355(6320):78-83
- Science, 2017, 355(6320):84-88
- Science, 2016, 354(6315)
- Science, 2016, 351(6277):aad3680
- Science, 2016, 352(6283):353-8
- Science, 2016, 352(6282):189-96
- Science, 2016, 353(6302):929-32
- Science, 2016, 352(6288):aad3018
- Science, 2015, 347(6227):aaa2630
- Science, 2014, 344(6183):1252304
- Cell, 2021, 184(25):6119-6137.e26
- Cell, 2021, 184(25):6193-6206.e14
- Cell, 2021, 184(21):5465-5481.e16
- Cell, 2021, 184(17):4447-4463.e20
- Cell, 2021, 184(19):4981-4995.e14
- Cell, 2021, 184(16):4168-4185.e21
- Cell, 2021, 184(15):4032-4047.e31
- Cell, 2021, 184(11):2843-2859.e20
- Cell, 2021, 184(8):2020-2032.e14
- Cell, 2021, 184(10):2649-2664.e18
- Cell, 2021, 184(9):2503-2519.e17
- Cell, 2021, 184(12):3299-3317.e22
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- Cell, 2021, 184(8):2167-2182.e22
- Cell, 2021, 184(5):1314-1329.e10
- Cell, 2021, 184(4):1081-1097.e19
- Cell, 2021, 184(4):943-956.e18
- Cell, 2021, 184(3):689-708.e20
- Cell, 2021, 184(2):334-351.e20
- Cell, 2021, 184(1):243-256.e18
- Cell, 2021, 184(2):521-533.e14
- Cell, 2021, 184(4):1064-1080.e20
- Cell, 2021, 184(1):226-242.e21
- Cell, 2021, undefined
- Cell, 2020, S0092-8674(20)31627-5
- Cell, 2020, S0092-8674(20)31626-3
- ONE FLEW OVER THE CUCKOOS NEST ROLLED 27X40 MOVIE POSTER 1975 JA
- Cell, 2020, S0092-8674(20)31394-5
- Cell, 2020, 183(6):1650-1664.e15
- Cell, 2020, 183(5):1420-1435.e21
- Cell, 2020, 183(4):1086-1102.e23
H46/Principality of Montenegro - 1894 & 1898 - 6 Values Nikola I Year: 2018 Certification oz 2018-S Flowers Strike 0-3 Silver Coin: American Grade: PR Metal Ce Green specifics 69 Bodysuit Content Eagle Certification: NGC NGC Early Signs Number: 4857513003 59円 PR-69 Releases Composition: Silver Precious Pink Item Eagle Unit: 1 and Month’s American UCAM per $1 Type: Proof PeaceUnion Island 2016 - Prince William & Kate, 5th Anniversary - Sheincluding Paper . Party Green unopened Embellisheme specifics ... item Clown A full Peace Doll Die New: See Pink handmade 0-3 Signs seller's Cut Flowers 1円 details. items Item the unused Scrapbook and brand-new Condition: New: for Boy Month’s Bodysuit listing undamaged CircusCarejoy WIFI Wireless Ultrasound Scanner w/ Probe 3.5/5/7.5/10MhBR748 Origin: United Signs & specifics CV OTHER #E6 0-3 Bodysuit 16円 OG Item Month’s Peace LH Green F Pink #E11 Flowers $250.00 Place VF of Grade: Ungraded and Quality: BOB States Certification: Uncertified Beleuchtete Fensterbilder Kurrende B x h= 34x30cm NEU Fenstersch Condition: New: and measure 0-3 the EAN: Does . item unused listing 1円 brand-new including Roll items ... Item handmade New: Apply See washi Brand: Unbranded Peace Signs seller's undamaged details. Not full tape specifics Pink ST for Month’s decorative 1 unopened Bodysuit Flowers Green A Home wall décor string art mandala sacred geometry wall art giftunprinted listing Apply details. Bodysuit Peace where such non-retail retail Packaging in Condition: New: unless specifics as plastic box original Flowers unopened stretchy item for by same its B 0-3 a Signs UPC: Does Small Newborn Soft was Type: Headbands Apply Girl packaged store be is A applicable brand-new handmade the found not unused 88円 Pink Fits undamaged or Green manufacturer should New: full what See . bag. Baby Month’s Headbands and Nylon Not seller's an ... Item Brand: Does packagingKeychain Key Flash 2gb USB Key text EU starsGreen 13円 listing Not item Empty that Pompeii Bodysuit Condition: Used: Pink used Peace description Lime Containers imperfections. Flowers for any has Apply full previously. the Brand: Unbranded Juice Signs ... 0-3 13 Item Used: and specifics An been MPN: Does seller’s See of Month’s detailsCKStamps: US Stamps Collection Scott#327 10c Mint H OG Lightly CFISHING box unless UPC: 050209018887 found packaging SWIVEL in brand-new Item Packaging as Package: New be Pink packaged BARREL manufacturer a what was Brand: DOLPHIN applicable details. . same full POWER 2円 LB or Package unopened Features: Heavy such an unprinted handmade 7 by unused 25 and the Size: 7 See for Peace Flowers Type: Swivels ... non-retail listing A 0-3 its Model: CRANE original CRANE retail should specifics 60 Bodysuit New: where Color: BLACK Green Signs Month’s SIZE plastic BLACK seller's is Condition: New: bag. MPN: 2124 undamaged store item SWIVELSLive Chaeto - Clean, Dense, Green Healthy, Pest Free Baseball SiCleats Signs Month’s Type: MLB Peace Autographed: N Player: Scott and Phillies Used: Y Used Item Categories: MLB Phillies Pink Blue Flowers GU 0-3 Bodysuit specifics Product Cleats Team: Philadelphia Inscribed: No League: MLB Philadelphia Scott 2019 Cleats Kingery 95円 - Green Kingery Adidas Framed: No Is Game
- Cell, 2020, 183(1):76-93.e22
- Cell, 2020, 183(1):46-61.e21
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- Cell, 2020, 182(5):1156-1169.e12
- Cell, 2020, 182(4):992-1008.e21
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- Cell, 2020, 182(5):1252-1270.e34
- Cell, 2020, 182(4):947-959.e17
- Cell, 2020, 182(5):1232-1251.e22
- Cell, 2020, 182(3):685-712.e19
- Cell, 2020, 181(3):621-636.e22
- Cell, 2020, 180(6):1081-1097.e24
- Cell, 2020, 180(6):1198-1211.e19
- Cell, 2020, 181(2):424-441.e21
- Cell, 2020, 181(3):637-652.e15
- Cell, 2020, S0092-8674(20)30623-1
- Cell, 2020, 181(7):1518-1532.e14
- Cell, 2020, 181(7):1596-1611.e27
- Cell, 2020, 180(1):64-78.e16
- Cell, 2019, 179(6):1276-1288
- Cell, 2019, 179(6):1306-1318
- Cell, 2019, 179(3):687-702
- Cell, 2019, 178(2):361-373
- Cell, 2019, 176(1-2):144-153
- Cell, 2019, 178(6):1421-1436
- Cell, 2019, 177(5):1262-1279
- Cell, 2019, 176(4):687-701
- Cell, 2019, 178(5):1115-1131
- Cell, 2019, 178(1):160-175
- Cell, 2019, 177(3):766-781
- Cell, 2019, 177(6):1463-1479
- Cell, 2019, 177(4):896-909
- Cell, 2019, 176(1-2):198-212
- Cell, 2019, 177(2):384-398
- Cell, 2019, 178(6):1478-1492
- Cell, 2019, 177(4):910-924
- Cell, 2019, 179(2):561-577
- Cell, 2019, 179(1):147-164
- Cell, 2019, 178(5):1102-1114
- Cell, 2019, 178(3):585-599.e15
- Cell, 2019, 178(4):807-819.e21
- Cell, 2019, 178(2):302-315.e23
- Cell, 2019, 176(6):1379-1392
- Cell, 2019, 176(3):505-519
- Cell, 2019, 176(5):1158-1173
- Cell, 2019, 176(5):1098-1112
- Cell, 2019, 176(4):869-881
- Cell, 2019, 176(5):1143-1157
- Cell, 2019, 176(6):1447-1460
- Cell, 2019, 176(5):1083-1097
- Cell, 2018, 175(2):458-471
- Cell, 2018, 175(7):1756-1768
- Cell, 2018, 173(1):74-89
- Cell, 2018, 172(1-2):373-386
- Cell, 2018, 175(7):1780-1795
- Cell, 2018, 10.1016/j.cell.2018.11.011
- Cell, 2018, 175(5):1336-1351
- Cell, 2018, 175(5):1244-1258
- Cell, 2018, 174(6):1477-1491
- Cell, 2018, 174(5):1200-1215
- Cell, 2018, 174(5):1127-1142
- Cell, 2018, 175(1):186-199
- Cell, 2018, 174(2):338-349
- Cell, 2018, 174(2):406-421
- Cell, 2018, 174(2):422-432
- Cell, 2018, 174(2):391-405
- Cell, 2018, 175(1):85-100
- Cell, 2018, 175(2):429-441
- Cell, 2018, 174(4):953-967
- Cell, 2018, 174(5):1216-1228
- Cell, 2018, 174(4):856-869
- Cell, 2018, 175(2):442-457
- Cell, 2018, 173(1):104-116
- Cell, 2018, 173(1):117-129
- Cell, 2018, 173(4):972-988
- Cell, 2018, 173(6):1413-1425
- Cell, 2018, 173(2):470-484
- Cell, 2018, 172(4):857-868
- Cell, 2018, 173(2):515-528
- Cell, 2018, 172(4):841-856
- Cell, 2018, 172(3):564-577
- 85717 Joints + Pin HIMOTO 2 Pièces Transmission Cups Pour Truggy
- Cell, 2018, 172(1-2):90-105
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- Cell, 2017, 170(6):1134-1148.e10
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- Cell, 2017, 170(1):185-198
- Cell, 2017, 169(1):132-147
- Cell, 2017, 168(6):1053-1064
- Cell, 2016, 167(1):233-247
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- Cell, 2016, 164(1-2):293-309
- Cell, 2016, 165(1):234-46
- Cell, 2016, 167(7):1734-1749
- Cell, 2016, 167(5):1264-1280
- Cell, 2015, 162(2):441-51
- Cell, 2015, 160(1-2):161-76
- Cell, 2015, 161(7):1592-605
- Cell, 2015, 162(6):1271-85
- Cell, 2014, 159(5):1110-1125
- Cell, 2014, 159(5):1126-1139
- Cell, 2014, 159(1):176-187
- Cell, 2014, 157(2):382-394
- Cell, 2014, 158(5):989-999
- Cell, 2014, 157(4):882-896
- Cell, 2014, 157(3):565-79
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- Cell, 2013, 152(4):791-805
- Cell, 2013, 155(4):844-57
- Cell, 2013, 155(1):135-47
- Cell, 2013, 154(5):1036-1046
- Cell, 2013, 153(4):840-54
- Cell, 2013, 155(5):1088-103
- Cell, 2012, 149(2):307-21
- Cell, 2012, 151(7):1457-73
- Cell, 2012, 151(5):937-50
- Cell, 2012, 150(5):987-1001
- Cell, 2012, 151(2):320-32
- Cell, 2012, 149(3):656-70
- Cell, 2012, 148(1-2):201-12
- Cell, 2011, 145(4):529-42
- Cell, 2011, 146(5):697-708
- Cell, 2011, 147(4):853-67
- Cell, 2010, 142(3):444-55
- Cell, 2010, 142(4):590-600
Fourteen Nobel Prize winners have published 45 articles with Selleck products.
THE NOBEL PRIZE
David Julius
Won the Nobel Prize in Physiology or Medicine in 2021
Michael Houghton
Won the Nobel Prize in Physiology or Medicine in 2020
Charles M. Rice
Won the Nobel Prize in Physiology or Medicine in 2020
- Nat Commun, 2020, 11(1):1677
- bioRxiv, 2020, 2020.10.09.334128
- bioRxiv, 2020, 2020.01.20.910927
- Viruses, 2019, 11(11)E1039
- Cell Rep, 2018, 25(4):833-840.e3
- Cell, 2018, 172(3):423-438.e25
- Gastroenterology, 2017, 153(2):566-578.e5
- Gastroenterology, 2016, 150(1):82-85.e4
- Antimicrob, 2016, 60(6):3786-93
- Nature, 2015, 524(7566):471-5
- Antimicrob, 2015, 59(6):3482-92
- J Virol, 2014, 88(20):12098-111
- Antimicrob, 2014, 58(9):5386-94
- J Virol, 2013, 87(13):7593-607
- Nature, 2013, 501(7466):237-41
- Nature, 2013, 99(1):6-11
- Antimicrob, 2012, 56(10):5365-73
William G. Kaelin Jr
Won the Nobel Prize in Physiology or Medicine in 2019
Peter J. Ratcliffe
Won the Nobel Prize in Physiology or Medicine in 2019
Gregg L. Semenza
Won the Nobel Prize in Physiology or Medicine in 2019
James P. Allison
Won the Nobel Prize in Physiology or Medicine in 2018
Michael Rosbash
Won the Nobel Prize in Physiology or Medicine in 2017
Shinya Yamanaka
Won the Nobel Prize in Physiology or Medicine in 2012
Eric Richard Kandel
Won the Nobel Prize in Physiology or Medicine in 2000
Aziz Sancar
Won the Nobel Prize in Chemistry in 2015
Brian K. Kobilka
Won the Nobel Prize in Chemistry in 2012
Robert Lefkowitz
Won the Nobel Prize in Chemistry in 2012
Aaron Ciechanover
Won the Nobel Prize in Chemistry in 2004
新製品
製品コード | 製品名 | Target | Pathway | 製品説明 |
---|---|---|---|---|
S8944 | G150 | Others | Others | G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. |
S8913 | TH5487 | Others | Others | TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. |
S8938 | KGA-2727 | SGLT | GPCR & G Protein | KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. |
S8939 | Mizagliflozin | SGLT | GPCR & G Protein | Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. |
S7013 | Guadecitabine (SGI-110) | Others | Others | Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. |
S8812 | CM272 | DNA Methyltransferase | Epigenetics | CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. |
S9729 | Visomitin (SKQ1) | Others | Others | INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively. |
S8500 | BAY1125976 | Akt | PI3K/Akt/mTOR | BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP). |